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Table 1 Commonly used AAV vector capsids, their origin, receptor usage and in vivo tropism

From: Optimization of AAV vectors to target persistent viral reservoirs

AAV capsid Naturally occuring Likely species origin Engineered AAV Receptor usage Other cellular receptor Co-receptors Tissue culture activity In vivo tissue tropism
AAV1 Y NHP N Y Sialic acid   Moderate Skeletal muscle, CNS, airway, retina, heart, liver
AAV2 Y Human N Y HSPG FGFR-1, HGFR, αVβ1 and αVβ5 integrins, Laminin receptor, CD9 Good Skeletal muscle, CNS, retina, liver
AAV3 Y Human N Y HSPG FGFR-1, HGFR, Laminin receptor Moderate Skeletal muscle, liver
AAV4 Y African green monkey N N Sialic acid Unknown Poor CNS, retina, kidney, lung
AAV5 Y Human N Y Sialic acid PDGFR Poor Skeletal muscle, CNS, airway, retina
AAV6 Y Human N Y HSPG, Sialic acid EGFR Moderate Skeletal muscle, airway, heart
AAV7 Y Rhesus macaque N Unknown Unknown Unknown Poor Skeletal muscle, CNS, retina, liver
AAV8 Y Rhesus macaque N Y Unknown Laminin receptor Poor Skeletal muscle, CNS, airway, retina, heart, liver
AAV9 Y Human N Y Galactose Laminin receptor Poor Skeletal muscle, CNS, airway, retina, heart, liver
AAV.rh10 Y Rhesus macaque N Unknown Unknown Laminin receptor Poor Skeletal muscle, CNS, airway, retina, heart, liver
AAV.DJ N NA Y Unknown HSPG Unknown Good Liver, CNS, retina
AAV.LK03 N NA Y Unknown Unknown Unknown Poor Human liver
  1. Bold—used widely to target in vivo
  2. NHP unknown non human primate, NA not applicable, HSPG Heparan sulfate proteoglycan, FGFR fibroblast growth factor receptor, HGFR hepatocyte growth factor receptor, PDGFR Platelet derived growth factor receptor, EGFR epidermal growth factor receptor, CNS Central nervous system