From: Optimization of AAV vectors to target persistent viral reservoirs
AAV capsid | Naturally occuring | Likely species origin | Engineered | AAV Receptor usage | Other cellular receptor | Co-receptors | Tissue culture activity | In vivo tissue tropism |
---|---|---|---|---|---|---|---|---|
AAV1 | Y | NHP | N | Y | Sialic acid | Â | Moderate | Skeletal muscle, CNS, airway, retina, heart, liver |
AAV2 | Y | Human | N | Y | HSPG | FGFR-1, HGFR, αVβ1 and αVβ5 integrins, Laminin receptor, CD9 | Good | Skeletal muscle, CNS, retina, liver |
AAV3 | Y | Human | N | Y | HSPG | FGFR-1, HGFR, Laminin receptor | Moderate | Skeletal muscle, liver |
AAV4 | Y | African green monkey | N | N | Sialic acid | Unknown | Poor | CNS, retina, kidney, lung |
AAV5 | Y | Human | N | Y | Sialic acid | PDGFR | Poor | Skeletal muscle, CNS, airway, retina |
AAV6 | Y | Human | N | Y | HSPG, Sialic acid | EGFR | Moderate | Skeletal muscle, airway, heart |
AAV7 | Y | Rhesus macaque | N | Unknown | Unknown | Unknown | Poor | Skeletal muscle, CNS, retina, liver |
AAV8 | Y | Rhesus macaque | N | Y | Unknown | Laminin receptor | Poor | Skeletal muscle, CNS, airway, retina, heart, liver |
AAV9 | Y | Human | N | Y | Galactose | Laminin receptor | Poor | Skeletal muscle, CNS, airway, retina, heart, liver |
AAV.rh10 | Y | Rhesus macaque | N | Unknown | Unknown | Laminin receptor | Poor | Skeletal muscle, CNS, airway, retina, heart, liver |
AAV.DJ | N | NA | Y | Unknown | HSPG | Unknown | Good | Liver, CNS, retina |
AAV.LK03 | N | NA | Y | Unknown | Unknown | Unknown | Poor | Human liver |