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Table 1 Commonly used AAV vector capsids, their origin, receptor usage and in vivo tropism

From: Optimization of AAV vectors to target persistent viral reservoirs

AAV capsid

Naturally occuring

Likely species origin

Engineered

AAV Receptor usage

Other cellular receptor

Co-receptors

Tissue culture activity

In vivo tissue tropism

AAV1

Y

NHP

N

Y

Sialic acid

 

Moderate

Skeletal muscle, CNS, airway, retina, heart, liver

AAV2

Y

Human

N

Y

HSPG

FGFR-1, HGFR, αVβ1 and αVβ5 integrins, Laminin receptor, CD9

Good

Skeletal muscle, CNS, retina, liver

AAV3

Y

Human

N

Y

HSPG

FGFR-1, HGFR, Laminin receptor

Moderate

Skeletal muscle, liver

AAV4

Y

African green monkey

N

N

Sialic acid

Unknown

Poor

CNS, retina, kidney, lung

AAV5

Y

Human

N

Y

Sialic acid

PDGFR

Poor

Skeletal muscle, CNS, airway, retina

AAV6

Y

Human

N

Y

HSPG, Sialic acid

EGFR

Moderate

Skeletal muscle, airway, heart

AAV7

Y

Rhesus macaque

N

Unknown

Unknown

Unknown

Poor

Skeletal muscle, CNS, retina, liver

AAV8

Y

Rhesus macaque

N

Y

Unknown

Laminin receptor

Poor

Skeletal muscle, CNS, airway, retina, heart, liver

AAV9

Y

Human

N

Y

Galactose

Laminin receptor

Poor

Skeletal muscle, CNS, airway, retina, heart, liver

AAV.rh10

Y

Rhesus macaque

N

Unknown

Unknown

Laminin receptor

Poor

Skeletal muscle, CNS, airway, retina, heart, liver

AAV.DJ

N

NA

Y

Unknown

HSPG

Unknown

Good

Liver, CNS, retina

AAV.LK03

N

NA

Y

Unknown

Unknown

Unknown

Poor

Human liver

  1. Bold—used widely to target in vivo
  2. NHP unknown non human primate, NA not applicable, HSPG Heparan sulfate proteoglycan, FGFR fibroblast growth factor receptor, HGFR hepatocyte growth factor receptor, PDGFR Platelet derived growth factor receptor, EGFR epidermal growth factor receptor, CNS Central nervous system