From: The role of SOCS proteins in the development of virus- induced hepatocellular carcinoma
Virus | SOCS protein | In vivo or In vitro | Viral proteins | Mechanism | References |
---|---|---|---|---|---|
HCV | SOCS1/3 | Hep-G2 cell | HCV core protein | Inhibit IFN-α induced expression of 2′,5′-OAS and MxA | [40] |
SOCS3 | patients | HCV genotype 1 | Reduce the biological response to IFN-α | [43] | |
SOCS1 | PBMC | HCV core protein | Dysregulate T- and B-cell signalling | ||
SOCS | Myeloid DCs | HCV genotype 3 | Diminish capacity to present antigen | [49] | |
SOCS3/7 | Huh-7 | HCV genotype 3 | Downregulation of IRS1 and IRS2 | ||
HBV | SOCS3 | Huh-7 and liver specimens from HBV-infected patients | adenoviral AdHBV (genotype A) | Dysregulate STAT/SOCS-signalling | [58] |
SOCS1 | HepG2.2.15 cells and PBMC | HBV antigen, HBeAg | Promote inflammatory cytokine production | [60] | |
SOCS1 | plasmacytoid dendritic cells | HBsAg | Inhibition of the IFN-α production | [61] | |
SOCS1/3 | HBV transgenic mice | CTP-HBcAg18-27-tapasin | enhance T cell immune responses |