TY - JOUR AU - Haddad, Coral Orel AU - Kalt, Inna AU - Shovman, Yehuda AU - Xia, Lei AU - Schlesinger, Yehuda AU - Sarid, Ronit AU - Parnas, Oren PY - 2021 DA - 2021/03/17 TI - Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells JO - Virology Journal SP - 56 VL - 18 IS - 1 AB - Kaposi’s sarcoma-associated herpesvirus (KSHV) is a transforming gammaherpesvirus. Like other herpesviruses, KSHV infection is for life long and there is no treatment that can cure patients from the virus. In addition, there is an urgent need to target viral genes to study their role during the infection cycle. The CRISPR-Cas9 technology offers a means to target viral genomes and thus may offer a novel strategy for viral cure as well as for better understanding of the infection process. We evaluated the suitability of this platform for the targeting of KSHV. SN - 1743-422X UR - https://doi.org/10.1186/s12985-021-01527-x DO - 10.1186/s12985-021-01527-x ID - Haddad2021 ER -