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Table 2 Summary of upregulated proteins in A549 cells infected with influenza A H5N1 virus compared to H9N2-infected cells at 24 hpi (r > 2, p < 0.05)

From: Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9

Spot no.a

Accession No.b

GENE

Protein name

MW (Da)

pI

Scorec

17*

P30084

ECHS1

Enoyl-CoA hydratase, mitochondrial

31,716

6.05

68

18

P02768

ALB

Serum albumin

47,098

5.92

64

19

P35527

KRT9

Keratin, type I cytoskeletal 9

62,255

5.14

72

20

Q9HC85

MB2

Metastasis related protein

10,414

5.16

35

21

P11021

HSPA5

Endoplasmic reticulum chaperone BiP

71,002

5.23

155

22

AIZ70879

N/A

immunoglobulin heavy chain variable region, partial

8328

11.84

42

23*

P34931

HSPA1L

heat shock 70-kDa protein 1-like

77,913

7.55

64

24

A0A1L1UHR1

HTL-T-186e

Homo sapiens sperm binding protein 1aing mRNA

30,868

8.62

46

25

P09651

HNRNPA1

Heterogeneous nuclear ribonucleoprotein A1

34,289

9.27

58

26

P22626

HNRNPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1

36,041

8.67

52

27

P08670

VIM

vimentin isoform 1, partial

53,676

5.06

56

28

Q8N1N4

KRT78

Keratin, type II cytoskeletal 78

57,728

5.79

51

29

Q86Y46

KRT73

Keratin, type II cytoskeletal 73

42,270

8.42

51

30

D9YZU9

HBG2

TPA: globin B2

16,173

6.64

50

31

P68871

HBB

Beta globin

11,534

5.9

46

32

P69905

HBA1

Hemoglobin subunit alpha

15,174

8.73

65

  1. aSpot No. is the unique sample spot protein number
  2. bAccession No is the MASCOT result of MALDI-TOF/TOF searched from the NCBI database
  3. cProtein score (based on combined MS and MS/MS spectra) and best ion score (based on MS/MS spectra) were from MALDI-TOF/TOF identification
  4. *Indicating that the differential proteins were validated by western blot analysis