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Fig. 4 | Virology Journal

Fig. 4

From: Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Fig. 4

Enhanced antiviral cytokine secretion by msiHBx-directed HBV silencing. HepG2 cells were transfected with msiHBx, siHBx, or siNC alone or cotransfected with 1 μg of the HBV replication-competent plasmid pHY106-X15. The levels of IFN-α (a), IFN-β (b), TNF (c), IL-1α (d), and IL-6 (e) in supernatants were detected at 72 h after transfection by ELISA. ns, no significant difference. *p < 0.05. **p < 0.01. ***p < 0.001. siNC was purchased from Sangon Biotech (Shanghai, China) and used as a negative control. siHBx, siRNA targeting the HBV X gene. msiHBx, msiRNA targeting the HBV X gene

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Virology Journal

ISSN: 1743-422X