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Fig. 2 | Virology Journal

Fig. 2

From: Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Fig. 2

Comparison of siRNAs and msiRNAs in their ability to knock down HBsAg expression. HepG2 cells were cotransfected with 1 μg of the HBV replication-competent plasmid pHY106-wta (a) or pHY106-X15 (b) and msiHBs, msiHBx, siHBs, or siHBx at various concentrations or with 20 nM siNC as a negative control. The levels of HBsAg in supernatants were detected by ELISA at 72 h after transfection. ns, no significant difference. *p < 0.05. **p < 0.01. ***p < 0.001. siNC was purchased from Sangon Biotech (Shanghai, China) and used as a negative control. siHBs, siRNA targeting the HBV S gene. siHBx, siRNA targeting the HBV X gene. msiHBs, msiRNA targeting the HBV S gene. msiHBx, msiRNA targeting the HBV X gene

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