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Fig. 2 | Virology Journal

Fig. 2

From: Packaging signal of influenza A virus

Fig. 2

A model for IAV life cycle. IAVs enter host cells by binding the cell surface receptors containing sialic acid. The vRNPs are released into the cytoplasm after the endocytosis and fusion of the viral and endosomal membranes. The incoming vRNAs of IAV remain associated until they are imported into the nuclei of infected cells. The vRNA replicates and transcribes in the nuclei of infected cells and are transported as vRNPs. After exporting from the nucleus, more than one vRNP assembled en route to the plasma membrane and exported from the nucleus as complex. That is, vRNPs together with the Rab11 protein are recruited to the tubulated endoplasmic reticulum (ER) that on irregularly coated vesicles (ICVs). The ICVs loaded with vRNP and Rab11 then bud from the ER and possibly transferred to the plasma membrane. At the final stage, the vRNPs are interconnected at the budding tip of the virion and are oriented perpendicularly. The progeny virions are then released by enzymatic cleavage of the viral receptor mediated by NA protein

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