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Fig. 2 | Virology Journal

Fig. 2

From: Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

Fig. 2

The depletion of Cohesin components inhibits HSV-1 replication compartments formation. a Western blot results show the efficiency of SMC1 and Rad21 knockdown by shRNA in BJ cells. b BJ cells were infected with HSV-1 at an MOI 5 for 5.5 h. Immunofluorescence results show the effects of SMC1 and Rad21 knockdown on HSV-1 replication compartment formation. c ICP4 staining patterns were defined as diffused, small foci, and large foci (left panel) to quantify the effects of SMC1 and Rad21 know-downs. The right panel shows the quantification analysis of ICP4 patterns before and after the Cohesin components knockdown

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