No
|
St19pv
|
VSVpv
|
---|
Serum (IC50)
|
#6
|
× 1600
|
× 25
|
#7
|
> × 6400
|
× 50
|
#12
|
× 1600
|
× 25
|
#20
|
× 3200
|
< × 25
|
#21
|
× 400
|
< × 25
|
#22
|
× 200
|
< × 25
|
#23
|
× 400
|
< × 25
|
Whole blood (IC50)
|
#6
|
× 1600
|
× 100
|
#7
|
> × 6400
|
× 100
|
#12
|
× 1600
|
× 100
|
#20
|
× 1600
|
× 100
|
#21
|
× 800
|
× 100
|
#22
|
× 400
|
× 100
|
#23
|
× 400
|
× 100
|
- The pseudotyped viruses, St19pv or VSVpv, were preincubated with serial dilutions (× 25, × 50, × 100, × 200, × 400, × 800, × 1600, × 3200, × 6400) of serum or whole blood from seven different COVID-19 hospitalized patients (patients #6, #7, #12, #20, #21, #22, and #23) with culture media. Thereafter, Vero cells were infected with pseudotyped viruses. Infectivities of pseudotyped viruses were determined by measuring luciferase activities 24 h post-infection. IC50 value was calculated and determined as shown in the dilution range. The results are from three independent assays with error bars representing standard deviations