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Table 2 The 50% inhibitory concentration of infection (IC50) of St19pv and VSVpv by serum or whole blood from COVID-19 hospitalized patients

From: Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein

No St19pv VSVpv
Serum (IC50)
#6  × 1600  × 25
#7  >  × 6400  × 50
#12  × 1600  × 25
#20  × 3200  <  × 25
#21  × 400  <  × 25
#22  × 200  <  × 25
#23  × 400  <  × 25
Whole blood (IC50)
#6  × 1600  × 100
#7  >  × 6400  × 100
#12  × 1600  × 100
#20  × 1600  × 100
#21  × 800  × 100
#22  × 400  × 100
#23  × 400  × 100
  1. The pseudotyped viruses, St19pv or VSVpv, were preincubated with serial dilutions (× 25, × 50, × 100, × 200, × 400, × 800, × 1600, × 3200, × 6400) of serum or whole blood from seven different COVID-19 hospitalized patients (patients #6, #7, #12, #20, #21, #22, and #23) with culture media. Thereafter, Vero cells were infected with pseudotyped viruses. Infectivities of pseudotyped viruses were determined by measuring luciferase activities 24 h post-infection. IC50 value was calculated and determined as shown in the dilution range. The results are from three independent assays with error bars representing standard deviations
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Virology Journal

ISSN: 1743-422X