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Table 1 Characteristics of PML patients

From: JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis

 

HIV

Risk factor

CSF composition

CD4/CD8 ratio (blood)

CSF JCPyV-DNA IU/mL

NCCR organization

Case 1

negative

natalizumab

glucose: 54 mg/dl proteins: 569 mg/L cell count: 5 cells/μl

0.45

1.62 × 106

A–B*–C–E–F

Case 2

negative

dimethyl fumarate

glucose: 56 mg/dl proteins: 35 mg/L cell count: 2 cells/μl

5.36

4.9 × 105

A–B–C–(D)–E–F

Case 3

positive

HIV infection

glucose: 76 mg/dl proteins: 413 mg/L cell count: 2 cells/μl

0.10

8.97 × 105

A-B-(C)-(E)-(F)-(B)-(C)-(E)-F*

Case 4

positive

HIV infection

glucose: 43 mg/dl proteins: 46 mg/L cell count: 2 cells/μl

0.11

2.34 × 106

A–C*–E*–F*

  1. Letter in brackets indicates the presence of a rearranged block. Asterisk (*) indicates a single nucleotide polymorphism. CSF cerebrospinal fluid, JCPyV JC polyomavirus, NCCR non-coding control region