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Fig. 1 | Virology Journal

Fig. 1

From: JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis

Fig. 1

The JCPyV NCCR sequences from CSF of four PML patients. The JCPyVNCCR sits between the viral early gene large T and the late gene agnoprotein and is a 267 base pairs sequence, in the archetype CY strain. The 267 bases are conventionally organized into 6 unequal fragments, namely from A to F: A from 1 to 36, B from 37 to 59, C from 60 to 114, D from 115 to 180, E from 181 to 198, F from 199 to 267 bases [12, 20]. Archetype CY and Mad-1 NCCRs are shown for comparison. Delated blocks are represented in grey with dotted lines. Asterisk (*) represents single nucleotide polymorphism. Transcription factor binding sites are represented by triangles. TATA: tata box; LCP: lytic control element-binding protein; SP-1: specificity protein-1; NF-1a: nuclear transcription factor 1a; SF2/ASF: splicing factor 2/alternative spicing factor; NF-1b: nuclear transcription factor-1b; AP-1: activating protein-1

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