TY - JOUR AU - Ma, Yan AU - Tang, Kang AU - Zhang, Yusi AU - Zhang, Chunmei AU - Zhang, Yun AU - Jin, Boquan AU - Ma, Ying PY - 2020 DA - 2020/01/31 TI - Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells JO - Virology Journal SP - 15 VL - 17 IS - 1 AB - Hantaan virus (HTNV) can cause hemorrhagic fever with renal syndrome (HFRS) in humans with severe morbidity and high mortality. Although inactivated HFRS vaccines are given annually for prevention in populations, China still has the highest number of HFRS cases and deaths worldwide. Consequently, vaccination for HFRS requires the development of novel, more effective vaccines. Epitope peptide vaccines have been developed rapidly in recent years and are considered a novel approach for the prevention of infection. Specifically, the multiple antigenic peptide (MAP) design with preferable immunogenicity can arouse a satisfactory immune response for vaccination. However, there are few reports on the design and evaluation of MAP for HTNV. SN - 1743-422X UR - https://doi.org/10.1186/s12985-020-1290-x DO - 10.1186/s12985-020-1290-x ID - Ma2020 ER -