Isolation of Ontario aquatic bird bornavirus 1 and characterization of its replication in immortalized avian cell lines

Table 1 Replication of avian bornaviruses in cell cultures

Virus	Quail			Chicken		Mammalian			Primary			References
Virus	CEC-32	QM-7	QT-6	DF-1	LMH	VERO	MDCK	C6	DEF	CEF	QEF	References
ABBV-1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	Yes	n/a	n/a	[4]
ABBV-2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	Yes	n/a	n/a	[27]
CnBV-1	Yes^a	Yes	n/a	Yes	Yes	No^b	n/a	n/a	Yes	n/a	n/a	[28]
CnBV-2	Yes	Yes	n/a	Yes	Yes	Yes	n/a	n/a	Yes	n/a	n/a	[28]
CnBV-3	Yes	Yes	n/a	Yes	Yes	No	n/a	n/a	Yes	n/a	n/a	[28]
EsBV-1	Yes	Yes	n/a	Yes	Yes	Yes	n/a	n/a	Yes	n/a	n/a	[29]
PaBV-1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	Yes	No	n/a	[30]
PaBV-2	Yes	Yes	Yes	n/a	Yes	No	No	No	Yes	n/a	n/a	[31,32,33,34]
PaBV-4	Yes	Yes	Yes	n/a	n/a	n/a	n/a	n/a	Yes	No	n/a	[30, 33, 34]
PaBV-5	n/a	n/a	No	n/a	n/a	n/a	n/a	n/a	Yes	n/a	No	[35]
PaBV-7	Yes	Yes	n/a	Yes	Yes	No	n/a	n/a	Yes	n/a	n/a	[31]

^aindicates detectable replication in cell line
^bindicates no detectable replication in cell line
n/a indicates no data available
DEF Primary duck embryo fibroblasts, CEF Primary chicken embryo fibroblasts, QEF Primary quail embryo fibroblasts, CEC-32 Immortalized quail embryo fibroblasts, QM-7 Immortalized quail smooth muscle cells (derivative of QT-6), QT-6 Immortalized quail fibrosarcoma cells (6 to 24 days old bird), DF-1 Immortalized chicken embryo fibroblasts, LMH Immortalized chicken hepatoma cell line, VERO Immortalized African green monkey kidney cells, MDCK Immortalized Madin-Darby Canine Kidney, C6 Immortalized rat glial cells