Fig. 3

Higher expression of MCP-1 in mild COVID-19 patients was negatively correlated with IRF3 expression. a RNA samples were extracted from PBMCs of mild COVID-19 patients (n = 20) and healthy controls (n = 10), and IRF3 was detected by RT-qPCR. IRF3 expression was significantly downregulated in mild COVID-19 patients. b Cytokine levels in serum of study subjects were detected by ELISA. IFN-β levels in serum of peripheral blood from mild COVID-19 patients were lower than in peripheral-blood serum from healthy controls. c SCC analysis was performed to analyze serum MCP-1 and expression level of IRF3. IRF3 expression was significantly negatively correlated with MCP-1 concentration. The correlation coefficient r² represents the degree of correlation. **P < 0.01, r² = 0.861