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Table 1 Cytotoxicity and effective concentrations of integrase inhibitors in the TZM-bl cell system

From: Study on suitable analysis method for HIV-1 non-catalytic integrase inhibitor

 

CC50 (nM)

EC50 (nM)

SI value

BI 224436

> 50,000.00

566.40

> 88.28

EVG

26,041.67

< 0.15

> 173,611.13

RAL

> 50,000.00

10.38

> 4816.96

DTG

> 50,000.00

1.60

> 31,250.00

  1. CC50, Half maximal cell cytotoxicity concentration; EC50, Half maximal effective concentration, SI value, Selectivity index, CC50/EC50