Fig.1
From: Study on suitable analysis method for HIV-1 non-catalytic integrase inhibitor
Determination of antiviral activities of integrase inhibitors in the TZM-bl cell line system. Integrase inhibitors were serially diluted and incubated with 1 × 104 TZM-bl cells per well during 30 min, followed by infection with 500 TCID50 of HIV-1 AD8 strain. For determination of antiviral efficacy, luciferase activity was measured after 48 h of incubation. Cell culture media of non-infected and infected cells without HIV drug treatment were set as the negative and positive control, respectively. EVG, Elvitegravir; RAL, Raltegravir; DTG, Dolutegravir