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Table 1 Univariate analysis of factors associated with HR-HPV load

From: Analysis of influencing factors of viral load in patients with high-risk human papillomavirus

Variables Parameters Number of patients (%) Simple endocervical sampling Combination of endo-and ectocervical sampling
Mean (SD) of log10 transformed viral load rs-valuea P-value Mean (SD) of log10 transformed viral load rs-valuea P-value
Age (years) 20–29 52 (19.0) 0.57 (± 0.62) 0.417 0.001 0.76 (± 0.61) 0.349 0.001
30–39 91 (33.3) 0.92 (± 0.73)    1.11 (± 0.67)   
40–49 99 (36.3) 1.16 (± 0.78)    1.29 (± 0.78)   
50–59 25 (9.2) 1.41 (± 0.69)    1.63 (± 0.72)   
60–69 6 (2.2) 2.52 (± 0.13)    2.56 (± 0.17)   
Lesion severity Negative 90 (33.0) 0.79 (± 0.39) 0.371 0.002 0.88 (± 0.35) 0.424  < 0.001
LSIL 93 (34.1) 0.87 (± 0.91)    1.03 (± 0.89)   
HSIL/CC 90 (33.0) 1.41 (± 0.81)    1.66 (± 0.70)   
Multiple HPV types No 200 (73.3) 0.92 (± 0.71) 0.198 0.060 1.08 (± 0.65) 0.237 0.024
Yes 73 (26.7) 1.29 (± 0.93)    1.48 (± 0.95)   
Area of lesions (cm2) 0.0–0.49 174 (63.7) 0.95 (± 0.74) 0.292 0.017 1.04 (± 0.70) 0.364  < 0.001
0.5–0.99 46 (16.8) 1.03 (± 0.72)    1.22 (± 0.69)   
1.0–1.49 24 (8.8) 0.93 (± 0.82)    1.41 (± 0.75)   
1.5–1.99 6 (2.2) 1.64 (± 0.94)    1.80 (± 0.77)   
2.0–2.49 10 (3.7) 1.76 (± 0.86)    1.90 (± 0.73)   
2.5–2.99 7 (2.6) 0.27 (± 0.14)    0.72 (± 0.01)   
3.0–3.49 6 (2.2) 2.43 (± 0.41)    2.89 (± 0.06)   
Location of lesions (cm)  ≤ 0.5 125 (68.3) 1.05 (± 0.72) − 0.017 0.891 1.21 (± 0.65) − 0.129 0.222
 > 0.5 58 (31.7) 0.90 (± 1.01)    1.10 (± 1.09)   
  1. Negative negative for intraepithelial lesion or malignancy, LSIL low-grade squamous intraepithelial lesion, HSIL/CC high-grade squamous intraepithelial lesion and/or cervical cancer
  2. aSpearman correlation coefficient. SD, standard deviation. Location of lesions, the distance between the external orifice of the uterus and the below bound of the lesions. ≤ 0.5 cm, involvement of the area bounded below by the ectocervix within a 0.5-cm radius of the external orifice of the uterus; > 0.5 cm, involvement of the area bounded below by the ectocervix over a 0.5-cm radius of the external orifice of the uterus. Multiple HPV types, at least two or more genotypes of HR-HPV infection
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