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Table 2 Mean KD values through One site-Specific binding analysis for interactions between HA antigen protein and a serial dilution of either 3′SL- or 6′SL-labeled receptors in each HA expression protein

From: Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

HAs

KD FOR 3′SL (μM)

KD FOR 6′SL (μM)

Anhui/1 & Shanghai/2 HA7

0.635 ± 0.188

0.753 ± 0.197

HA7 A135T

5.553 ± 1.232

0.147 ± 0.031

HA7 T71I

3.627 ± 0.518

0.388 ± 0.102

HA7 T157I

3.176 ± 0.921

0.231 ± 0.051

HA7 T71I-V223I

2.189 ± 0.518

0.127 ± 0.028

HA7 T71I-T157I-V223I

2.189 ± 0.204

0.268 ± 0.081

HA7 T71I-T157I-V223I-T40I

3.317 ± 0.300

0.231 ± 0.051

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Virology Journal

ISSN: 1743-422X