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Fig. 5: | Virology Journal

Fig. 5:

From: Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

Fig. 5:

3D structures of interactions between the HA protein and receptors analyzed by Flusurver (https://flusurver.bii.a-star.edu.sg/INTERACTIONS/) (a) 3D structures of HA7 color-marked mutation sites and receptors; (b) Shanghai/2 HA mutation Thr40Ile and ligand NAG (pink atoms); (c) Anhui/1 HA mutation Ala135Thr and ligand GLC (pink atoms), host cell receptor SIA (pink atoms). (d) Shanghai/2 HA mutation A107T on viral chain A (yellow backbone), within 5 A from oligomeric subunit chain F (blue backbone); (e) Shanghai/2 HA mutation G218E on viral chain A (yellow backbone), within 5 A from oligomeric subunit chain C (blue backbone); (f) Shanghai/2 HA mutation T157I on viral chain A (yellow backbone), within 5 A from ligand EPE (pink atoms); (g) Shanghai/2 HA mutation V218I on viral chain A (yellow backbone), within 5 A from ligand EPE (pink atoms)

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