Table 1 Results of inhibition profiling of HIV protease inhibitors against SARS-CoV-2 Mpro in cell culture. Data are calculated from triplicate experiments. IC50 for lopinavir was indeterminable accurately due to high cytotoxic effects in HEK-293 T cells
From: Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main protease
Inhibitor | IC50 (µM) | Standard error |
|---|---|---|
Lopinavir + Ritonavir | 10.9 | ± 1.1 |
Ritonavir | 13.7 | ± 1.1 |
Saquinavir | 31.4 | ± 1.2 |
Darunavir | 36.1 | ± 1.2 |
Atazanavir | 60.7 | ± 2.5 |
Lopinavir | Indeterminable | |
Indinavir | No inhibition (up to 200 µM) | |
Nelfinavir | No inhibition (up to 200 µM) | |
Tipranavir | No inhibition (up to 200 µM) | |