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Table 1 Results of inhibition profiling of HIV protease inhibitors against SARS-CoV-2 Mpro in cell culture. Data are calculated from triplicate experiments. IC50 for lopinavir was indeterminable accurately due to high cytotoxic effects in HEK-293 T cells

From: Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main protease

Inhibitor IC50 (µM) Standard error
Lopinavir + Ritonavir 10.9  ± 1.1
Ritonavir 13.7  ± 1.1
Saquinavir 31.4  ± 1.2
Darunavir 36.1  ± 1.2
Atazanavir 60.7  ± 2.5
Lopinavir Indeterminable
Indinavir No inhibition (up to 200 µM)
Nelfinavir No inhibition (up to 200 µM)
Tipranavir No inhibition (up to 200 µM)