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Fig. 4 | Virology Journal

Fig. 4

From: Luteolin inhibits respiratory syncytial virus replication by regulating the MiR-155/SOCS1/STAT1 signaling pathway

Fig. 4

Luteolin enhances STAT1 phosphorylation and ISRE luciferase activity. a A549 cells were pre-treated with 50 μM luteolin for 24 h before infected with RSV at MOI = 0.05. At the indicated hours post infection, proteins were extracted for western blotting to detect the JAK, STAT1 phosphorylation. b A549 cells were transfected with pISRE-TA-luc for 24 h and cells were treated with luteolin for 24 h before infected with RSV. At 12 or 24 h post infection, cells were collected, and luciferase activities were determined. Data shown are means ± SEM. Statistical significance was examined by Students’ t-test. P < 0.05 was considered statistically significant. *P < 0.05, ***P < 0.001. STAT1 signal transducers and activators of transcription 1, MOI multiplicity of infection, JAK Janus-activated kinase, ISRE interferon-stimulated response element, RSV respiratory syncytial virus

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