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Fig. 2 | Virology Journal

Fig. 2

From: Inflammatory response and MAPK and NF-κB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans

Fig. 2

Natural infection with street RABV strains induces chemokine secretion in dog and human brain tissues. a–c The Proteome Profiler Array Mouse Cytokine Array Panel A was used to detect the protein expression levels of 40 cytokines and chemokines in brain tissues from dogs and humans naturally infected with the street RABV strains CGS-17 and CXZ-15. Uninfected dog brains served as the control group. d The quantitative analysis results for the relative signal densities of chemokines in the group of brains infected with CGS-17 and CXZ-15 normalized to those in the control group are shown. e The protein expression levels of CXCL1, CCL2, CCL5, and CXCL12 in the brain tissues of mice infected with CGS-17 and CXZ-15 were measured by ELISA. Uninfected mouse brains served as the control group. Data are expressed as the mean ± SD from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, versus the noninfected group

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Virology Journal

ISSN: 1743-422X