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Fig. 1 | Virology Journal

Fig. 1

From: Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice

Fig. 1

Details of the primary sequences of Hantaan virus (HTNV) linear multi-epitope peptides. The top row shows the HLA-A*02-restricted single HTNV-GP CD8+ T-cell epitope with the amino acid sequence VMASLVWPV defined as “VV9”. The bottom row shows the HTNV linear multi-epitope peptide, consisting of the same HLA-A*0201-restricted HTNV CTL epitope VV9 in tandem with Pan HLA-DR T helper epitope (PADRE, AKXVAAWTLKAAA, X = cyclohexylalanine), defined as “PADRE-VV9”. The K-S-S was used as the adaptor sequence and the A-A-A in PADRE was used as the linker sequence for the multi-epitope peptides connection. CTL, cytotoxic T lymphocyte. X* indicates cyclohexylalanine

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