Fig. 5
From: HLA-associated protection of lymphocytes during influenza virus infection
Influenza Virus (IAV)-specific Cytotoxicity is Related to HLA-A Determinants and Target Cell Populations. This representative image shows results using cells from HLA-A2-homozygous donor number 4. Cytotoxic T lymphocyte (CTL) activity was measured as specific lysis of autologous targets consisting of monocytes/macrophages (Δ), or lymphocytes/lymphoblasts (○), or unseparated PBMC (□). Results show virus-specific lysis of autologous target cell populations infected with the strain of virus used to induce CTL (A/Marton/43 H1N1). The graphs show CTL activity and autologous target cell susceptibilities for PBMC and subpopulations from (a) a heterozygous (A1,11) individual and (b) a homozygous (A2, −) individual. Results are representative of three experiments using PBMC from different heterozygous and homozygous donors tested concurrently