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Fig. 2 | Virology Journal

Fig. 2

From: BK polyomavirus infection promotes growth and aggressiveness in bladder cancer

Fig. 2

BKPyV infection promotes proliferation, invasion and migration of bladder cancer cells. a, b BKPyV infection significantly increased growth in T24 and HTB-9 cells, as measured by colony formation. ch BKPyV infection significantly promoted migration of T24 and HTB-9 cells, as measured by the Transwell migration assay (c, d) and wound healing assay (eh) after infected with BKPyV 48 h. i, j Transwell invasion assay showed that BKPyV infection significantly promoted invasiveness of T24 and HTB-9 cells. These effect was significantly reversed by KYA1797K. All images were taken at 100× magnification. All graphs represent the mean ± SD obtained from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001; + BKV versus control; + BKV + KYA1797K versus + BKV; Student’s t-test or one-way ANOVA

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