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Table 4 NA genetic mutations compared with A/Brisbane/02/2018 (N1 numbering)

From: Characterization of neuraminidase inhibitor-resistant influenza virus isolates from immunocompromised patients in the Republic of Korea

Virus

Amino acid identity with A/Brisbane/02/2018 (%)

T13I

I29M

Q51K

F74S

P93Sa,b

I99Vb

H275Yc

G298Aa

V321Ia

V394Ib

D416Na,b

T452Ia,b,d

A/Korea/S0003/2019

98.3

  

  

A/Korea/S0002/2019

98.5

 

  

   

Frequency (%)

99.79

0.65

18.14

16.78

0.34

0.89

0.58

0.75

1.13

1.37

36.25

18.76

  1. substitution of the amino acid indicated
  2. aBinding small ligand
  3. bviral oligomerization interfaces
  4. cstrong drug resistance
  5. dbinding host protein