Table 3 Viruses that induces a pseudohypoxic state

Influenza

HIF1α stabalization

Impaired proteasome function results in decreased degradation of HIF1α

A549

[123]

Hepatitis B Virus (HBV)

HIF1α stabalization

HBx inhibits binding of VHL to HIF2α

HepG2, L02

[68]

HIF1α stabalization

HBx activates MAPK pathway which in turns induces the activity of HIF1α

Chang X-34, HepG2

[153]

VACV

HIF1α stabalization

C16 inhibition of PHD2

Hek293T

[100]

EBV

Increased protein synthesis of HIF1α

LMP induced

KR-4

[141]