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Table 2 Summary of viruses inhibited and augmented by hypoxia

From: Oxygen: viral friend or foe?

 

Mechanism

Cell Line

Conditions

Reference

Inhibited

 Adenovirus

Cell arrest

H1299 / A549

1% oxygen

[119, 132]

 SV40

Blocks replication

CV1

0.02% oxygen

[124]

 H1 parvovirus

ND

 

Constitutive expression of HIF1α

[25]

 VSV

Increase in innate immune responses

RCC

Constitutive expression of HIF1α

[69]

Augmented

 DENV

Increased antibody dependent uptake via upregulation of FcγRIIA and membrane ether lipid concentrations

THP-1, Primary Monocytes

3% oxygen

[46]

Correlated with increased anaerobic glycolysis for increased ATP production

Huh7

3% oxygen

[42]

 EBV

Induce reactivation of EBV

Burkitt lymphoma Sal

Deferoxamine (DFX)

[90]

 HSV

Hypoxia induced GADD34

U87

5% oxygen

[2]

 HCV

ATP increase due to the induction of anaerobic glycolysis

Huh7.5

3% oxygen

[139]

 Sendai Virus

ND

Rhabdomyosarcoma

3 Kpa

[37]

 KSHV

HIF1α induction of viral Rta promoter

Hep3B

Expression of reporter plasmids containing Rta promoter

[58]

  1. ND Not determined