Promising application of monoclonal antibody against chikungunya virus E1-antigen across genotypes in immunochromatographic rapid diagnostic tests

Table 2 Evaluation of 2nd-generation CHIKV E1 detection RDT version B in clinical samples

IgG/IgM	PCR	IC RDT		Sensitivity	Specificity	OAA
IgG/IgM	PCR	(+)	(−)	Sensitivity	Specificity	OAA
(−)	(+)	4	1	80.0		92.5
(−)	(−)	2	33		94.3
(+)	(+)	7	14	33.3		47.5
(+)	(−)	7	12		63.2
Total	(+)	11	15	42.6		70.0
Total	(−)	9	45		83.3

IgG/IgM (−): anti-CHIKV IgM- and IgG-negative cases
IgG/IgM (+): anti-CHIKV IgM- or IgG-positive cases
Sensitivity: percentage of matches between results of PCR and IC RDT in PCR positive samples
Specificity: percentage of matches between results of PCR and IC RDT in PCR negative samples
OAA overall agreement (percentage of total matches between results of PCR and IC RDT)

ISSN: 1743-422X