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Fig. 6 | Virology Journal

Fig. 6

From: The role of host eIF2α in viral infection

Fig. 6

The translation regulation of ATF4 under stress conditions. ATF4 translation is regulated through upstream open reading frames (uORFs). The 5′-proximal uORF1 encodes three amino acid residues, and the uORF2 and ATF4 coding regions partially overlap. In nonstressed cells, uORF1 facilitates ribosome scanning and reinitiates at the downstream coding region, uORF2, which blocks ATF4 expression. Under stress conditions, the time required for scanning ribosomes to reinitiate translation increases; thus, uORF1 allows ribosomes to scan through uORF2 and to initiate the ATF4-coding region [129]

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