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Fig. 1 | Virology Journal

Fig. 1

From: The role of host eIF2α in viral infection

Fig. 1

eIF2α phosphorylation inhibits translation initiation. The GTP conversion factor eIF2B converts inactive eIF2-GDP into active eIF2-GTP. The 43S complex containing eIF2-GTP scans along the mRNA for the initiation codon AUG. Once eIF2α is phosphorylated, the function of eIF2B to convert eIF2-GDP to eIF2-GTP is weakened or disappears, eventually leading to translational initiation inhibition [1,2,3]

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Virology Journal

ISSN: 1743-422X