Fig. 3From: Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cellsEvaluating the Inhibitory Effect on PRRSV Infection by Compounds Structurally Similar to B7. a Molecular structures of B7 analogues (B7-A1 to A6) compared with B7. b BiFC assay between SRCR5-VN and GP2a-VC proteins. Representative fluorescent images showing different effects between compound B7 and its analogues on the SRCR5-GP2a PPI, with DMSO as the Ctrl. Bar = 250 μm. c Relative fluorescence intensity in (b) quantified by Fiji. Mean ± SD, n = 3. **: P < 0.01, ***: P < 0.001. ns: non-significant. d qRT-PCR for PRRSV in total RNAs extracted from PRRSV strain VR-2332 infected PAMs treated with 15 μM of B7 and its analogues. Values are normalized with GAPDH of PAMs. Bars = mean ± SD, n = 3. *: P < 0.05, **: P < 0.01. e Titration assay results for PRRSV in the culture media of PAMs treated as described in (d). Bars = mean ± SD, n = 3. *: P < 0.05, **: P < 0.01. ns: non-significantBack to article page