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Table 4 Genotype and allele frequencies of LIN28B rs314277, rs314280, rs369065 and rs7759938 in patients with different clinical diseases

From: Association of LIN28B polymorphisms with chronic hepatitis B virus infection

 AC (n = 91)CH (n = 128)LC (n = 127)HCC (n = 169)χ2P
rs314277Genotype      
CC84 (92.3)124 (96.9)117 (92.1)159 (94.1)Reference 
AC7 (7.7)4 (3.1)10 (7.9)10 (5.9)3.1210.373
AA0 (0)0 (0)0 (0)0 (0)
Allele      
C175 (96.2)252 (98.4)244 (96.1)328 (97.0)Reference 
A7 (3.8)4 (1.6)10 (3.9)10 (3.0)3.0240.388
rs314280Genotype      
GG51 (56.0)86 (67.2)74 (58.3)102 (60.4)Reference 
GA34 (37.4)33 (25.8)45 (35.4)58 (34.3)4.2030.240
AA6 (6.6)9 (7.0)8 (6.3)9 (5.3)0.3130.958
Allele      
G136 (74.7)205 (80.1)193 (76.0)262 (77.5)Reference 
A46 (25.3)51 (19.9)61 (24.0)76 (22.5)2.0720.558
rs369065Genotype      
TT40 (44.0)70 (54.7)50 (39.4)79 (46.7)Reference 
TC37 (40.7)37 (28.9)62 (48.8)74 (43.8)9.9120.019
CC14 (15.4)21 (16.4)15 (11.8)16 (9.5)2.0650.559
Allele      
T117 (64.3)177 (69.1)162 (63.8)232 (68.6)Reference 
C65 (35.7)79 (30.9)92 (36.2)106 (31.4)2.7110.438
rs7759938Genotype      
TT53 (58.2)88 (68.8)72 (56.7)104 (61.5)Reference 
TC31 (37.1)32 (25.0)46 (36.2)57 (33.7)4.5860.205
CC7 (7.7)8 (6.3)9 (7.1)8 (4.7)1.4490.694
Allele      
T137 (75.3)208 (81.2)190 (74.8)265 (78.4)Reference 
C45 (24.7)48 (18.8)64 (25.2)73 (21.6)3.8020.284
  1. AC chronic asymptomatic carrier, CH chronic hepatitis, LC liver cirrhosis, HCC hepatocellular carcinoma. Data are presented as n (%). Genotype frequencies were estimated using the direct counting method. Chi-square test was used for analysis