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Table 4 Genotype and allele frequencies of LIN28B rs314277, rs314280, rs369065 and rs7759938 in patients with different clinical diseases

From: Association of LIN28B polymorphisms with chronic hepatitis B virus infection

 

AC (n = 91)

CH (n = 128)

LC (n = 127)

HCC (n = 169)

χ2

P

rs314277

Genotype

      

CC

84 (92.3)

124 (96.9)

117 (92.1)

159 (94.1)

Reference

 

AC

7 (7.7)

4 (3.1)

10 (7.9)

10 (5.9)

3.121

0.373

AA

0 (0)

0 (0)

0 (0)

0 (0)

–

–

Allele

      

C

175 (96.2)

252 (98.4)

244 (96.1)

328 (97.0)

Reference

 

A

7 (3.8)

4 (1.6)

10 (3.9)

10 (3.0)

3.024

0.388

rs314280

Genotype

      

GG

51 (56.0)

86 (67.2)

74 (58.3)

102 (60.4)

Reference

 

GA

34 (37.4)

33 (25.8)

45 (35.4)

58 (34.3)

4.203

0.240

AA

6 (6.6)

9 (7.0)

8 (6.3)

9 (5.3)

0.313

0.958

Allele

      

G

136 (74.7)

205 (80.1)

193 (76.0)

262 (77.5)

Reference

 

A

46 (25.3)

51 (19.9)

61 (24.0)

76 (22.5)

2.072

0.558

rs369065

Genotype

      

TT

40 (44.0)

70 (54.7)

50 (39.4)

79 (46.7)

Reference

 

TC

37 (40.7)

37 (28.9)

62 (48.8)

74 (43.8)

9.912

0.019

CC

14 (15.4)

21 (16.4)

15 (11.8)

16 (9.5)

2.065

0.559

Allele

      

T

117 (64.3)

177 (69.1)

162 (63.8)

232 (68.6)

Reference

 

C

65 (35.7)

79 (30.9)

92 (36.2)

106 (31.4)

2.711

0.438

rs7759938

Genotype

      

TT

53 (58.2)

88 (68.8)

72 (56.7)

104 (61.5)

Reference

 

TC

31 (37.1)

32 (25.0)

46 (36.2)

57 (33.7)

4.586

0.205

CC

7 (7.7)

8 (6.3)

9 (7.1)

8 (4.7)

1.449

0.694

Allele

      

T

137 (75.3)

208 (81.2)

190 (74.8)

265 (78.4)

Reference

 

C

45 (24.7)

48 (18.8)

64 (25.2)

73 (21.6)

3.802

0.284

  1. AC chronic asymptomatic carrier, CH chronic hepatitis, LC liver cirrhosis, HCC hepatocellular carcinoma. Data are presented as n (%). Genotype frequencies were estimated using the direct counting method. Chi-square test was used for analysis