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Table 3 LIN28B rs7759938 genotype and allele frequencies in patients with chronic HBV infection, HBV infection resolvers and healthy controls

From: Association of LIN28B polymorphisms with chronic hepatitis B virus infection

 Patients
(n = 515)
Resolvers
(n = 97)
Controls
(n = 169)
Patients vs. resolversPatients vs. controlsResolvers vs. controls
POR (95%CI)POR (95%CI)POR (95%CI)
Genotype
 CodominantTT317 (61.6)50 (51.5)85 (50.3)Reference Reference Reference 
TC166 (32.2)38 (39.2)75 (44.4)0.1130.689 (0.434–1.093)0.005a0.593 (0.413–0.853)0.5760.861 (0.510–1.454)
CC32 (6.2)9 (9.3)9 (5.3)0.1500.561 (0.253–1.245)0.9040.953 (0.438–2.074)0.2891.700 (0.633–4.565)
 DominantTT317 (61.6)50 (51.5)85 (50.3)Reference Reference Reference 
TC + CC198 (38.4)47 (48.5)84 (49.7)0.0650.664 (0.430–1.028)0.0100.632 (0.445–0.897)0.8440.951 (0.577–1.567)
 RecessiveTT + TC483 (93.8)88 (90.7)160 (94.7)Reference Reference Reference 
CC32 (6.2)9 (9.3)9 (5.3)0.2710.648 (0.299–1.404)0.6731.178 (0.550–2.521)0.2221.818 (0.696–4.748)
 OverdominantTT + CC349 (67.8)59 (60.8)94 (55.6)Reference Reference Reference 
TC166 (32.2)38 (39.2)75 (44.4)0.1840.739 (0.472–1.155)0.0040.594 (0.418–0.850)0.4090.807 (0.486–1.342)
 Additive 0.0580.725 (0.520–1.010)0.0330.741 (0.562–0.977)0.8480.962 (0.645–1.435)
Allele
 T800 (77.7)138 (71.1)245 (72.5)Reference Reference Reference 
C230 (22.3)56 (28.9)93 (27.5)0.0480.708 (0.503–0.999)0.0510.757 (0.572–1.002)0.7381.069 (0.723–1.582)
  1. Data are presented as n (%). aPc (P value by Bonferroni correction) = 0.010. Genotypic association tests between groups assuming codominant, dominant or log-additive genetic models were carried out by univariate logistic regression using SNPstats and odds ratios (OR) with 95% confidence interval (CI) were calculated. Multiple testing correction was performed by the Bonferroni method