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Table 2 LIN28B rs314280 genotype and allele frequencies in patients with chronic HBV infection, HBV infection resolvers and healthy controls

From: Association of LIN28B polymorphisms with chronic hepatitis B virus infection

 Patients
(n = 515)
Resolvers
(n = 97)
Controls
(n = 169)
Patients vs. resolversPatients vs. controlsResolvers vs. controls
POR (95%CI)POR (95%CI)POR (95%CI)
Genotype
 CodominantGG313 (60.8)49 (50.5)83 (49.1)Reference Reference Reference 
GA170 (33.0)38 (39.2)76 (45.0)0.1300.700 (0.441–1.113)0.005a0.593 (0.413–0.853)0.5350.847 (0.501–1.433)
AA32 (6.2)10 (10.3)10 (5.9)0.0740.501 (0.232–1.083)0.6681.178 (0.401–1.797)0.2711.694 (0.658–4.358)
 DominantGG313 (60.8)49 (50.5)83 (49.1)Reference Reference Reference 
AA+GA202 (39.2)48 (49.5)86 (50.9)0.0590.659 (0.426–1.018)0.0080.623 (0.439–0.884)0.8260.945 (0.574–1.558)
 RecessiveGG + GA483 (93.8)87 (89.7)159 (94.1)Reference Reference Reference 
AA32 (6.2)10 (10.3)10 (5.9)0.1480.576 (0.273–1.215)0.8891.053 (0.506–2.191)0.1961.828 (0.732–4.562)
 OverdominantGG + AA345 (67.0)59 (60.8)93 (55.0)Reference Reference Reference 
GA170 (33.0)38 (39.2)76 (45.0)0.2400.765 (0.489–1.196)0.0050.603 (0.423–0.859)0.3580.788 (0.474–1.310)
 Additive0.0380.705 (0.507–0.981)0.0360.744 (0.564–0.981)0.7090.927 (0.624–1.378)
Allele
 G796 (77.3)136 (70.1)242 (71.6)Reference Reference Reference 
 A234 (22.7)58 (29.9)96 (28.4)0.0310.689 (0.491–0.969)0.0340.741 (0.561–0.978)0.7141.075 (0.730–1.584)
  1. Data are presented as n (%). aPc (P value by Bonferroni correction) = 0.010. Genotypic association tests between groups assuming codominant, dominant or log-additive genetic models were carried out by univariate logistic regression using SNPstats and odds ratios (OR) with 95% confidence interval (CI) were calculated. Multiple testing correction was performed by the Bonferroni method