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Table 4 Incidence of amino acid mutation/ deletion between HBsAg+/HBsAb+ group (Group I) and HBsAg+/HBsAb- group (Group II)

From: Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies

Section of PreS & HBsAg

Number of substitutions per 100 amino acid residues

Group I

Group II

χ2

P value

PreS1(aa1–118)

0.44

0.26

1.836

0.18

PreS2(aa1–54)

1.92

2

0.190

0.89

PreS deletiona

11.11

0.64

11.801

< 0.001

S protein

Full-length of S protein (aa1–226)

1.03

0.31

21.19

< 0.001

N-terminal (aa1–99)

1.08

0.21

25.6

< 0.001

MHR (aa100–169)

0.85

0.17

17.6

< 0.001

a determinant (aa124 ~ 147)

1.54

0.06

30.1

< 0.001

First loop (aa124–137)

1.59

0.10

20.954

< 0.001

Second loop (aa139–147)

1.06

0.00

20.804

< 0.001

C-terminal (aa170 ~ 226)

1.54

0.06

30.1

< 0.001

  1. aPreS deletion incidence was calculated by number of deletions per 100 samples
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Virology Journal

ISSN: 1743-422X