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Table 3 Main nucleotide and amino acid mutations of HBV CD1 and CD2 isolates in Qinghai-Tibet Plateau

From: Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies

Position Nucleotide mutation Amino acid mutation CD1(130 isolates) CD2(49 isolates) Total (179 isolates) P value
BCP T1753C   6 4.62% 9 18.37% 15 8.38% 0.003
nt1742–1849 A1762T   35 26.92% 18 36.73% 53 29.61% 0.2
G1764A   38 29.23% 18 36.73% 56 31.28% 0.334
A1762T + G1764A   32 24.62% 18 36.73% 50 27.93% 0.107
PreC/C region G1896A W28* 17 13.08% 3 6.12% 20 11.17% 0.188
nt1814–2452 G1899A G29D 5 3.85% 1 2.04% 6 3.35% 0.55
A1984G   4 3.08% 38 77.55% 42 23.46% < 0.001
C1990T   0 0 21 42.86% 21 11.73% < 0.001
C2002T   2 1.54% 0 0 2 1.12% 0.383
A2075G I88V 6 4.62% 0 0 6 3.35% 0.126
A2159G S116G 3 2.31% 3 6.12% 6 3.35% 0.206
A2189C I126L 13 10% 10 20.41% 23 12.85% 0.064
C2198A L129I 9 6.92% 5 10.20% 14 7.82% 0.466
C2288A P159T 27 20.77% 15 30.61% 42 23.46% 0.166
PreS/S gene T53C F130L 5 3.85% 3 6.12% 8 4.47% 0.511
nt2881–835 T150AC L162PQ 121 93.08% 10 20.41% 131 73.18% < 0.001
C129T S155L 19 14.62% 0 0 19 10.61% 0.005
G774A S207N 43 33.08% 0 0 43 24.02% < 0.001
C3026T A49V 8 6.15% 5 10.20% 13 7.26% 0.352
T3098C I73T 3 2.31% 0 0 3 1.68% 0.284
C3121A P81T 8 6.15% 0 0 8 4.47% 0.076
C3189A D103E 4 3.08% 0 0 4 2.23% 0.214
P gene A2375C E23D 6 4.62% 41 83.67% 47 26.26% < 0.001
nt2307–1623 A2502T T66S 3 2.31% 17 34.69% 20 11.17% < 0.001
C2523G E73Q 2 1.54% 32 65.31% 34 18.99% < 0.001
A37G S316G 113 86.92% 4 8.16% 117 65.36% < 0.001
G49A V320I 10 7.69% 45 91.84% 55 30.73% < 0.001
G886A V599I 104 80% 0 0 104 58.1% < 0.001
G899A W603Y 0 0 49 100% 49 27.37% < 0.001
C930A Q617DH 4 3.08% 49 a 100%   
T1249G V720L 2 1.54% 46 b 93.88%%   
T1351G S754A 0 0 47 95.92% 47 26.26% < 0.001
G1484A C798Y 0 0 48 97.96% 48 26.82% < 0.001
C2712AT H136YN 97 74.62% 5 10.20% 102 56.98% < 0.001
C3051T P249S 120 92.31% 8 16.33% 128 71.51% < 0.001
A3057G T251A 56 43.08% 3 6.12% 59 32.96% < 0.001
A3108G S268G 43 33.08% 2 4.08% 45 25.14% < 0.001
A942T L613QH 129 99.23% 48 c 97.96%%   
T3210A S272TN 130 100% 49 100% 179 100%
X gene G1386AC V5ML 31 23.85% 0 0 31 17.32% < 0.001
nt1374–1838 G1515A, A1516C D48AN 20 15.38% 0 0 20 11.17% 0.04
G1613A   14 10.77% 2 4.08% 16 8.94% 0.162
C1653T H94Y 7 5.38% 3 6.12% 10 5.59% 0.848
T1633A Q87L 2 99.23% 46 93.88% 48 26.82% < 0.001
T1485C S38P 129 0.77% 49 100% 178 99.44%
  1. a Amino acid mutation E617DH for CD2
  2. b Amino acid mutation L720VS for CD2
  3. c Amino acid mutation H613K for CD2
  4. * means stop condon
  5. — means P value could not be calculated
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