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Fig. 6 | Virology Journal

Fig. 6

From: Pulmonary endothelium-derived PD-L1 induced by the H9N2 avian influenza virus inhibits the immune response of T cells

Fig. 6

Secretion of cytotoxic factors by the migrated T cells from H9N2 virus-infected rats. The RPMECs were divided into 3 groups: RPMECs from rats infected with the live H9N2 virus (Virus), RPMECs from rats inoculated with the inactivated H9N2 virus (Particle), RPMECs from rats infected the live H9N2 virus and then treated with a PD-L1-specific antibody (Antibody). Then the activated RPMECs were added to the T for 8 h. The levels of secreted IL-2 (a), IFN-γ (B b) and granzyme B (c) by T cells and the expression of perforin (d) post the different RPMECs cocultured with T cells. * indicates the particle or antibody group compared with the virus group. Statistical analysis of cytotoxic factors post treatment with RPMECs from H9N2 virus-infected rats, or RPMECs from the viral particles or the PD-L1 antibody (*P < 0.05, **P < 0.01)

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