Table 2 Host shutoff-associated proteins inhibit various proinflammatory cytokines and cytokines
From: Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion
Protein | Pathogen | Target protein | Mechanism |
|---|---|---|---|
VHS | HSV-1 | IL-1β, IL-8 | mRNA degradation |
MIP-1α | |||
NF-KB | |||
MHC-I/II | |||
RNase L | |||
JAK1 | |||
STAT2 | |||
SOCS3 | |||
VHS | BHV-1 | MHC-I/II | mRNA degradation |
BGLF5 | EBV | HLAI/II | mRNA degradation |
CD1d | |||
ICP27 | HSV-1 | NF-KB | Inhibition of NF-kB transcriptional activity by repressing Daxx sumoylation |
ICP27 | HSV-1 | p65 | Inhibition of p65 acetylation |
ICP27 | HSV-1 | STAT1 | Inhibition of STAT-1 phosphorylation and nuclear accumulation |
ICP27 | BHV-1 | IFNβ | Inhibition of IFN-β1/3 promoter activity |