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Table 2 Host shutoff-associated proteins inhibit various proinflammatory cytokines and cytokines

From: Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion

Protein Pathogen Target protein Mechanism
VHS HSV-1 IL-1β, IL-8 mRNA degradation
MIP-1α
NF-KB
MHC-I/II
RNase L
JAK1
STAT2
SOCS3
VHS BHV-1 MHC-I/II mRNA degradation
BGLF5 EBV HLAI/II mRNA degradation
CD1d
ICP27 HSV-1 NF-KB Inhibition of NF-kB transcriptional activity by repressing Daxx sumoylation
ICP27 HSV-1 p65 Inhibition of p65 acetylation
ICP27 HSV-1 STAT1 Inhibition of STAT-1 phosphorylation and nuclear accumulation
ICP27 BHV-1 IFNβ Inhibition of IFN-β1/3 promoter activity