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Fig. 5 | Virology Journal

Fig. 5

From: Identification of protein inhibitor of activated STAT 4, a novel host interacting partner that involved in bovine viral diarrhea virus growth

Fig. 5

The effect of PIAS4 expression on immunity response. a To determine the effect of PIAS4 expression on host cell survival. The expression of BAX and Bcl-2 was analyzed by western blot under the conditions that PIAS4 expression was changed and the cells were infected by BVDV. b Overexpression of PIAS4 inhibited the expression of SOCS3, IFITM3 IFN-ɑ and STAT4 in protein levels. c The expression of core protein downregulated antivirus protein expression when cells were transfected with siRNA (PIAS4). d The expression of ISG15, IFITM3, MX1, OAS1 was downregulated by interaction of PIAS4 and core protein

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Virology Journal

ISSN: 1743-422X