Skip to main content
Fig. 1 | Virology Journal

Fig. 1

From: Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment

Fig. 1

Differentiation and characterization of bone marrow mesenchymal stem cells (BM-MSCs). MSCs were isolated from the bone marrow of 6-8 week-old C57BL/6 mice by selective adherence to the plastic cell culture dishes. a Adipogenic (see black arrow) and b osteogenic (see white arrow) differentiation were evaluated by Oil Red O staining and Alizarin Red as described in the materials and methods. c Flow cytometry quantification of MSCs after isolation and enrichment showed the MSCs were positive for CD44 and CD105 but negative for CD34 and CD45 markers. d The cytotoxic effects of the different NDV MOIs on MSCs was evaluated by MTT assay at 72 h post-infection. Means are from 3 independent experiments and *(P < 0.05) indicates statistically significant difference between MOI 40 compared with control group

Back to article page

Virology Journal

ISSN: 1743-422X