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Fig. 6 | Virology Journal

Fig. 6

From: Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin

Fig. 6

Mice immunized with H3 HA/ERp57 showed less body weight loss against heterologous (H1N1) challenges than those immunized with H3 HA. BALB/c mice (n = 5) immunized with H3 HA or H3 HA/ERp57 were infected i.n. by 3 × MLD50 H1N1 viruses 3 weeks after the second immunization. The mice were monitored daily for their survival rates and body weight for 14 days. The body weight percentage was calculated according to the formula of (retained body weight/initial body weight) × 100%. The survival rate was calculated according to the formula of (number of survival mice/number of challenged mice) × 100%. a Weight loss of immunized mice against infection of H1N1 influenza virus, ** represents p < 0.01. b Survival rates of immunized mice against infection of H1N1 influenza virus, * represents p < 0.05

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