Table 3 The major acquired drug resistance mutations found in this study. The drug resistance mutations were identified using the Stanford University HIVdb algorithm
|  | 2012 (n = 42) | 2013 (n = 84) | 2014 (n = 201) | 2015 (n = 215) | 2016 (n = 209) | 2017 (n = 163) | Total (n = 914) |
|---|---|---|---|---|---|---|---|
PI | |||||||
 M46I/L | 0 | 4 | 2 | 4 | 5 | 4 | 14 (1.53%) |
 I84V | 0 | 0 | 1 | 1 | 1 | 1 | 4 (0.44%) |
 L76V | 0 | 0 | 1 | 3 | 5 | 2 | 11 (1.20%) |
 L90M | 0 | 0 | 1 | 1 | 1 | 0 | 3 (0.33%) |
 F53L | 0 | 0 | 0 | 1 | 0 | 0 | 1 (0.11%) |
 I50IV | 0 | 0 | 0 | 2 | 0 | 3 | 5 (0.55%) |
 I54L | 0 | 0 | 0 | 3 | 7 | 25 | 35 (3.83%) |
 V82L | 0 | 0 | 0 | 3 | 6 | 17 | 26 (2.84%) |
NRTI | |||||||
 M184V/I | 36 | 53 | 124 | 129 | 118 | 108 | 567 (62.04%) |
 T69S/D/N | 1 | 3 | 4 | 15 | 9 | 4 | 35 (3.83%) |
 T215D/S | 9 | 16 | 20 | 17 | 18 | 7 | 86 (9.41%) |
 M41L | 2 | 7 | 10 | 6 | 18 | 16 | 58 (6.35%) |
 K70Q/R | 10 | 12 | 21 | 34 | 36 | 26 | 138 (15.10%) |
 K65R | 3 | 6 | 33 | 50 | 43 | 51 | 185 (20.24%) |
 L210W | 4 | 6 | 6 | 3 | 9 | 5 | 32 (3.50%) |
 K70R/E | 10 | 13 | 20 | 34 | 36 | 26 | 138 (15.10%) |
 Y115F | 3 | 1 | 11 | 17 | 22 | 13 | 66 (7.22%) |
L74I | 1 | 2 | 11 | 15 | 20 | 10 | 58 (6.35%) |
NNRTI | |||||||
 K103N/S | 14 | 42 | 85 | 91 | 75 | 76 | 383 (41.90%) |
 K101E | 9 | 11 | 22 | 26 | 22 | 17 | 107 (11.71%) |
 Y181C | 11 | 26 | 69 | 64 | 49 | 39 | 257 (28.12%) |
 221Y | 6 | 12 | 17 | 9 | 16 | 6 | 66 (7.22%) |
 Y188H | 2 | 7 | 14 | 13 | 8 | 10 | 54 (5.91%) |
 G190A | 14 | 23 | 53 | 61 | 55 | 37 | 242 (26.48%) |
 P225H | 2 | 5 | 15 | 12 | 8 | 6 | 48 (5.25%) |
 A98 | 2 | 3 | 12 | 14 | 9 | 10 | 50 (5.47%) |
 V108I | 3 | 10 | 17 | 12 | 17 | 9 | 68 (7.44%) |
 V106M/A | 2 | 2 | 17 | 37 | 25 | 17 | 100 (10.94%) |
 L100I | 0 | 0 | 4 | 5 | 9 | 3 | 31 (3.39%) |
 M230L | 0 | 1 | 6 | 11 | 6 | 7 | 31 (3.39%) |