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Table 3 The major acquired drug resistance mutations found in this study. The drug resistance mutations were identified using the Stanford University HIVdb algorithm

From: Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China

 2012
(n = 42)
2013
(n = 84)
2014
(n = 201)
2015
(n = 215)
2016
(n = 209)
2017
(n = 163)
Total
(n = 914)
PI
 M46I/L04245414 (1.53%)
 I84V0011114 (0.44%)
 L76V00135211 (1.20%)
 L90M0011103 (0.33%)
 F53L0001001 (0.11%)
 I50IV0002035 (0.55%)
 I54L000372535 (3.83%)
 V82L000361726 (2.84%)
NRTI
 M184V/I3653124129118108567 (62.04%)
 T69S/D/N134159435 (3.83%)
 T215D/S916201718786 (9.41%)
 M41L27106181658 (6.35%)
 K70Q/R101221343626138 (15.10%)
 K65R3633504351185 (20.24%)
 L210W46639532 (3.50%)
 K70R/E101320343626138 (15.10%)
 Y115F311117221366 (7.22%)
L74I121115201058 (6.35%)
NNRTI
 K103N/S144285917576383 (41.90%)
 K101E91122262217107 (11.71%)
 Y181C112669644939257 (28.12%)
 221Y61217916666 (7.22%)
 Y188H27141381054 (5.91%)
 G190A142353615537242 (26.48%)
 P225H2515128648 (5.25%)
 A9823121491050 (5.47%)
 V108I310171217968 (7.44%)
 V106M/A2217372517100 (10.94%)
 L100I00459331 (3.39%)
 M230L016116731 (3.39%)
  1. Note: HIV drug resistance mutations were identified using the Stanford University HIVdb algorithm
  2. ART regimens