TY - JOUR AU - Li, Yujia AU - Yao, Min AU - Duan, Xiaoqiong AU - Ye, Haiyan AU - Li, Shilin AU - Chen, Limin AU - Yang, Chunhui AU - Chen, Yongjun PY - 2020 DA - 2020/04/05 TI - The USP18 cysteine protease promotes HBV production independent of its protease activity JO - Virology Journal SP - 47 VL - 17 IS - 1 AB - Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in antiviral defense by induced expression of a few hundred interferon stimulated genes (ISGs), including ubiquitin-specific protease 18 (USP18). The expression level of USP18 was elevated in the pretreatment liver tissues of chronic hepatitis B(CHB) patients who did not respond to IFN treatment. Thus, this study was designed to investigate the effects of USP18 on HBV replication/production. SN - 1743-422X UR - https://doi.org/10.1186/s12985-020-01304-2 DO - 10.1186/s12985-020-01304-2 ID - Li2020 ER -