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Table 6 Relation between demographic and clinical characteristics of patients with CMV mono-viral infection and CMV viral co-infection

From: Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy

VariablesNo active CMV infection
(N = 26)
No. (%)
Active CMV mono-infection
(N = 39)
No. (%)
Active CMV co-infection
(N = 19)
No. (%)
P
Sex
Male15 (57.7)23 (59)16 (84.2)0.119
Female11 (42.3)16 (41)3 (15.8) 
Age (years)
  < 1617 (65.4)22 (56.4)10 (52.6)0.655
  ≥ 169 (34.6)17 (43.6)9 (47.4) 
Type of Leukemia
 AML6 (23)21 (53.8)9 (47.4)0.044
 ALL20 (76.9)18 (46.2)10 (52.6) 
Status of disease
 Newly diagnosed1 (4)6 (15.4)2 (10.5)0.342
 Remission20 (76.9)24 (61.5)10 (52.6) 
 Refractory or relapse5 (19.1)9 (23)7 (36.8) 
Chemotherapy received
 Before chemotherapy1 (3.8)6 (15.4)2 (10.5)0.802
 Post-induction7 (26.9)10 (25.7)4 (21) 
 Post-remission8 (30.8)13 (33.3)7 (36.8) 
 Post-salvage chemotherapy10 (38.5)10 (25.6)6 (31.6) 
Clinical outcome
 Alive24 (92.3)34 (87.2)14 (73.7)0.198
 Dead2 (7.7)5 (12.8)5 (26.3) 
Fever16 (61.5)28 (71.8)12 (63.1)0.646
Severe neutropenia11 (42.3)24 (61.5)13 (68.4)0.163
Prolonged neutropenia8 (30.8)20 (51.3)10 (52.6)0.752
Severe lymphopenia11 (42.3)18 (46.2)16 (84.2)0.009
Anemia7 (26.9)15 (38.5)6 (31.6)0.507
Thrombocytopenia7 (26.9)16 (41)6 (31.6)0.364
Skin rash2 (7.7)6 (15.4)8 (42.1)0.011
Mucositis1 (3.8)2 (5.2)2 (10.5)
Pneumonia2 (7.7)7 (17.9)8 (42.1)0.016
Gastroenteritis7 (17.9)3 (15.8)0.084
Hepatitis2 (7.7)5 (12.8)5 (26.3)0.198
Conjunctivitis2 (5.2)
CNS disorders1 (3.8)2 (5.2)4 (21)0.073
Other infection    
BSI4 (15.4)4 (10.3)8 (42.1)0.013
IFI2 (7.7)5 (12.8)7 (36.8)0.024
  1. Viral infections were divided into three groups (1) no active CMV infection, (2) active mono-viral infection with only CMV and no other HHVs infection and (3) active co-infection with CMV and other HHVs
  2. Severe neutropenia [ANC < 500/μL]; Prolonged neutropenia [if it persisted over 7 days]; Severe lymphopenia [ALC < 500/μL]; Anemia: [hemoglobin < 11 g/L], Thrombocytopenia [platelet count < 100 10 3 /μL]; CNS disorders Central Nervous System disorders, BSI Blood Stream Infection, IFI Invasive Fungal Infection
  3. Statistically significant p are bolded