Risk Factors (Univariate analysis) | CMV infection | EBV infection | HHV-6 infection | HHV7- infection | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients Data | Negative N = 49 (%) | Positive N = 46 (%) | P | Negative N = 87 (%) | Positive N = 8 (%) | P | Negative N = 70 (%) | Positive N = 25 (%) | P | Negative N = 81(%) | Positive N = 14 (%) | P | |
Gender | Male | 31 (49.2) | 32 (50.8) | 0.516 | 56 (88.9) | 7 (11.1) | 0.260 | 44 (69.9) | 19 (30.1) | 0.233 | 54 (58.7) | 9 (14.3) | 0.862 |
Female | 18 (56.2) | 14 (43.8) | Â | 31 (96.9) | 1 (3.1) | Â | 26 (81.2) | 6 (18.8) | Â | 27 (84.4) | 5 (15.6) | Â | |
Age groups (years) | < 16 | 26 (53.1) | 23 (46.9) | 0.765 | 44 (89.8) | 5 (10.2) | 0.518 | 35 (71.4) | 14 (28.6) | 0.606 | 40 (81.6) | 9 (18.4) | 0.303 |
≥ 16 | 23 (50) | 23 (50) |  | 43 (93.5) | 3 (6.5) |  | 35 (76.1) | 11 (23.9) |  | 41 (89.1) | 5 (10.9) |  | |
Type of leukemia | AML | 18 (41.9) | 25 (58.1) | 0.085 | 41 (95.3) | 2 (4.7) | 0.286 | 32 (74.4) | 11 (25.6) | 0.882 | 37 (86) | 6 (14) | 0.845 |
ALL | 31 (59.6) | 21 (40.4) | Â | 46 (88.5) | 6 (11.5) | Â | 38 (73.1) | 14 (26.9) | Â | 44 (84.6) | 8 (15.4) | Â | |
Response to induction | Non-complete remission | 11 (44) | 14 (56) | 0.377 | 23 (92) | 2 (8) | 0.930 | 20 (80) | 5 (20) | 0.403 | 22 (88) | 3 (12) | 0.653 |
Complete remission | 38 (54.3) | 32 (45.7) | Â | 64 (91.4) | 6 (8.6) | Â | 50 (71.4) | 20 (28.6) | Â | 59 (84.3) | 11 (15.7) | Â | |
Disease status (at the last follow-up) | Remission | 33 (61.1) | 21 (38.9) | 0.033 | 51 (94.5) | 3 (5.5) | 0.248 | 45 (83.3) | 9 (16.7) | 0.014 | 48 (88.8) | 6 (11.2) | 0.253 |
Relapse/Refractory | 16 (39) | 25 (61) | Â | 36 (87.8) | 5 (12.2) | Â | 25 (61) | 16 (39) | Â | 33 (80.5) | 8 (19.5) | Â | |
Salvage | No received | 39 (59.1) | 27 (31.9) | 0.027 | 62 (93.9) | 4 (6.1) | 0.211 | 54 (81.8) | 12 (18.2) | 0.007 | 59 (89.4) | 7 (10.6) | 0.087 |
Received | 10 (34.5) | 19 (65.5) | Â | 25 (86.2) | 4 (13.8) | Â | 16 (55.2) | 13 (44.8) | Â | 22 (75.9) | 7 (24.1) | Â | |
Outcome | Death | 7 (41.2) | 10 (58.8) | 0.344 | 15 (88.2) | 2 (11.8) | 0.631 | 12 (70.6) | 5 (29.4) | 0.749 | 15 (88.2) | 2 (11.8) | 0.703 |
Alive | 42 (53.8) | 36 (46.2) | Â | 72 (92.3) | 6 (7.7) | Â | 58 (74.4) | 20 (25.6) | Â | 66 (84.6) | 12 (15.4) | Â | |
Virus | CMV infection | – | – | – | 43 (93.5) | 3 (6.5) | 0.716 | 27 (58.7) | 19 (41.3) | 0.001 | 38 (82.6) | 8 (17.4) | 0.479 |
EBV infection | 5 (62.5) | 3 (37.5) | 0.518 | – | – | – | 5 (62.5) | 3 (37.5) | 0.430 | 5 (62.5) | 3 (37.5) | 0.092 | |
HHV-6 infection | 6 (24) | 19 (76) | 0.001 | 22 (88) | 3 (12) | 0.430 | – | – | – | 22 (88) | 3 (12) | 0.754 | |
HHV-7 infection | 6 (42.8) | 8 (57.2) | 0.479 | 11 (78.6) | 3 (21.4) | 0.092 | 11 (78.6) | 3 (21.4) | 0.754 | – | – | – | |
Multivariate analysis for viral infection | Factors | Coefficient (B) | Odds Ratio (OR) | 95% Confidence Interval | P | Â | |||||||
CMV infection | HHV-6 infection | 1.436 | 4.205 | 1.450–12.198 | 0.008 |  | |||||||
HHV-6 infection | Salvage received | 1.060 | 2.887 | 1.048–7.955 | 0.040 |  | |||||||
CMV infection | 1.450 | 4.265 | 1.474–12.345 | 0.007 |  |