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Fig. 4 | Virology Journal

Fig. 4

From: EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses

Fig. 4

Significant decrease in EOS mRNA load in PBMCs of HTLV-1 infected individuals irrespective of their disease statuses. Expression of EOS mRNA in PBMCs was examined by real-time qRT-PCR. A. The expression level of EOS mRNA in HTLV-1 infected individuals was significantly lower than in NC, irrespective of their clinical statuses (i.e., AC, HAM or ATL). B. EOS mRNA levels in PBMCs of aggressive-ATL patients, such as acute- and lymphoma-types with poor prognosis, was significantly lower than indolent-ATL patients, such as smoldering- and chronic-types with relatively good prognosis (p = 0.023, Mann-Whitney U-test). C. HTLV-1 proviral load (PVL) in PBMCs of ATL patients. Mean HTLV-1 copy numbers per 104 PBMCs were presented in each group. The HTLV-1 PVL of aggressive-ATL patients was significantly higher than that of indolent-ATL patients (p = 0.041, Mann-Whitney U test)

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Virology Journal

ISSN: 1743-422X