Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways

Table 1 The inhibitory effects of PA against different IAV strains in vitro

Compound	Virus strains	Single-cycle replication assay^a	Multicycle replication assay^a
		Infectious virus titer	Plaque number
		IC₅₀ (μg/ml)^b	IC₅₀ (μg/ml)^b
PA	Vir09	6.3 ± 1.3	2.2 ± 0.2
	NWS	3.5 ± 1.4	3.2 ± 0.2
	PR8	6.1 ± 1.7	2.9 ± 0.4
Ribavirin	Vir09	0.1 ± 0.02	121.0 ± 22.1

^aSingle-cycle high-moi assays and multicycle plaque reduction assays were performed on MDCK cells infected with Vir09, NWS, and PR8. Values are means ± S.D. (n = 3)
^bInhibition concentration 50% (IC₅₀): concentration required to reduce the virus titer or plaque number by 50%

ISSN: 1743-422X