Skip to main content

Table 2 Antigenic characterization of wild-type and mutant H1N1 influenza A viruses by HI assay

From: Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

H1N1 virus

Titer a

Goat antiserum against CA/04

Ferret antiserum against:

mAbs against CA/04:

CA/04

A/CA/07/09

A/TN/1–560/09

28665

28666

28667

28668

CA/04V152I

0

0

0

0

0

0

0

0

CA/04G155E

-3

-3

-3

-3

>-5

1

1

>-6

CA/04S162N

1

0

1

0

0

1

−1

0

CA/04S183P

0

0

0

0

-2

−1

-1

0

CA/04D222G

−2

− 6

−3

− 4

>-5

0

0

>-6

  1. aValues represent the differences between the HI titers of antisera or mAbs (reciprocals of the serum/antibody dilutions that inhibited 8 hemagglutination units of virus) in the reactions with the wild-type CA/04 and mutant H1N1 viruses in log2 units