H1 HA mutation included in NAI package insertsa | HA mutations selected in cell culture/associated with reduced susceptibility to NAI in cell culture | Strains containing corresponding treatment-emergent HA mutation | Strains from untreated patients containing corresponding HA mutation (or HA mutation at the same residue) | Corresponding NAI package insert | |
---|---|---|---|---|---|
HA mutation (if different from listed) and/or stain, in which the HA mutation was observed | NA changes observed together with corresponding HA mutation | ||||
D125Sb (129) | A/Puerto Rico/8/34 (H1N1) [14] | ̶ | ̶ | RAPIVAB® [14] | |
L151P (154) | H151Q, A/Wuhan/259/95 (H1N1) [20] | E119V | A(H1N1)pdm09 [21] | ̶ | RELENZA® [13] |
V152I (155) | T152A, NWS/G70C (H1N9) [6]c,d | ̶ | ̶ | RELENZA® [13] | |
G155E (158) | A(H1N1)pdm09 [10]c,d | N146S | ̶ | ̶ | RELENZA® [13] |
S162 Ne (165) | NWS/G70C (H1N9) [7]c,d | ̶ | A(H1N1)pdm09 [23] | RELENZA® [13] | |
S183P (186) | S183F, NWS/G70C (H1N9) [7]c,d | E119G | ̶ | RELENZA® [13] | |
A197T (200) | A/WSN/33 (H1N1) [9]d | Deletion 92–362 | ̶ | A(H1N1)pdm09 [23] | RELENZA® [13] |
R208K (211) | A/Puerto Rico/8/34 (H1N1) [14] | ̶ | ̶ | ̶ | RAPIVAB® [14] |
D222G (225) | A/Hokkaido/15/02 (H1N1) [11]c | Y155H, V114I | ̶ | RELENZA® [13] |